Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite: A promising voltammetric platform for sensitive determination of doxorubicin

Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine

Abstract Background and purpose Doxorubicin (DOX) serves as an anthracycline-based chemotherapy drug to treat multiple types of cancers and sarcomas, which include lung, breast, bladder, leukaemia, liver, head and neck cancers. Experimental approach The electroanalysis of the trace level of DOX in this study was conducted using a Zn-Ni metal-organic framework nanosheets@graphene oxide nanocomposite (Zn-Ni MOF NSs@GO) after the modification of a screen-printed carbon electrode (Zn-Ni MOF NSs@GO/SPCE). Using chronoamperometry, cyclic voltammetry and differential pulse voltammetry, the electrochemical characteristics of the sensor as constructed for DOX measurement were examined. Key results Consequently, the composite sensor demonstrated exceptional electrocatalytic performance in oxidizing DOX within a concentration range of 0.004 to 190.0 μM, with a detection limit of 0.001 μM. It was found that the Zn-Ni MOF NSs@GO/SPCE was effective at determining DOX in real samples, with good recovery values in the 97.1 to 102.0 % range. Conclusion The designed sensor with cost-effective and good performance could be valuable for therapeutic drug monitoring and clinical diagnostics.