Triglyceride-Glucose Index and Risk of End-Stage Kidney Disease in Young Adults: National Population-Based Cohort Study

Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine

Abstract Background The triglyceride-glucose (TyG) index, a simple marker of insulin resistance, is associated with chronic kidney disease and end-stage kidney disease (ESKD). However, its association with ESKD in young adults remains unexplored. Objective This study aimed to investigate whether the TyG index increases the risk of ESKD in the young adult population. Methods This nationwide retrospective, population-based cohort study analyzed data from 6,555,863 individuals aged 20‐39 years between January 2009 and December 2012 using the Korean National Health Insurance Database. Participants were categorized into quartiles and deciles based on the TyG index. The cumulative incidence and adjusted hazard ratios for ESKD were assessed. Results Over a median follow-up period of 10.61 years, 4910 (0.75%) participants developed ESKD. The incidence of ESKD increased with a higher TyG index in quartiles and deciles. The adjusted hazard ratio for ESKD in the highest quartile was 3.438 (95% CI 3.096‐3.818) compared to the lowest quartile, and that in the highest decile was 5.944 (95% CI 5.022‐7.035) compared to the lowest decile. These associations remained consistent across subgroup analyses by age, sex, obesity, dyslipidemia, and chronic kidney disease. Conclusions The TyG index is significantly associated with ESKD risk in young adults.