Three-Color SUV-Normalized SPECT/CT to Visualize Dynamic Pulmonary Perfusion in Chronic Thromboembolic Pulmonary Hypertension.

Source: PubMed, NCBI / U.S. National Library of Medicine

Circulation reportsKishigami Daiki, Shimokawahara Hiroto, Takahashi Kazunori, et al.Published 6/10/2026Last synced 6/14/2026Status: syncedPMID: 42273321DOI: 10.1253/circrep.CR-26-0041

Conventional lung perfusion scintigraphy relies on relative tracer distribution and has limited utility for longitudinal assessment of regional pulmonary perfusion in chronic thromboembolic pulmonary hypertension (CTEPH). We applied CT-derived, lung volume-normalized standardized uptake value (SUV)-based 3-color SPECT/CT mapping in a patient with CTEPH undergoing staged balloon pulmonary angioplasty followed by pulmonary endarterectomy. This approach visualized regional perfusion redistribution and vascular steal patterns not clearly identified by conventional SPECT/CT and demonstrated close spatial concordance with pulmonary angiographic findings throughout multimodal treatment. SUV-normalized 3-color SPECT/CT enables intuitive visualization of dynamic pulmonary perfusion redistribution during staged interventions.

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