Severe hypertriglyceridemia due to heterozygous LPL variant, ApoE ε2ε2 genotype, and environmental interactions in an 11-year-old boy.

Source: PubMed, NCBI / U.S. National Library of Medicine

Severe hypertriglyceridemia in children is uncommon and typically results from a combination of acquired and genetic factors. We report the case of an 11-year-old boy with triglyceride levels exceeding 1700 mg/dL secondary to obesity, medication effects, and rare genetic variants. This case highlights the importance of early recognition, comprehensive evaluation, and evidence-based management to prevent acute complications such as pancreatitis and, in adulthood, premature cardiovascular disease.