Scleroderma

Source: MedlinePlus Health Topics, U.S. National Library of Medicine

Last synced 8/6/2026Status: primary verified

What is scleroderma? Scleroderma means "hard skin." It's the name of an autoimmune disease that causes inflammation and thickening in the skin and other areas of the body. This inflammation causes you to have areas of tight, hard skin. Scleroderma may affect just one area of your body, or it can affect many systems in your body. What are the types of scleroderma? There are two main types of scleroderma: Localized scleroderma only affects your skin and the muscles and tissues just under your skin. Systemic scleroderma, which is also called systemic sclerosis, is a more serious type. It affects many parts of your body and can damage your blood vessels and internal organs, such as your heart , lungs , and kidneys . What causes scleroderma? The exact cause of scleroderma is unknown. Researchers think that several factors may play a part in causing the disease: Your genetics. Certain genes can increase the chance that you will develop scleroderma. They may also play a role in which the type of scleroderma you have. Scleroderma is not passed from parent to child, but you are more likely to develop it if a close relative has it. Your environment. Exposure to certain things in the environment, such as viruses or chemicals, may trigger scleroderma. Immune system changes . When your immune system changes, it can trigger your cells to make too much collagen in the body. Too much collagen causes patches of tight, hard skin. Hormones . Hormonal or immune system differences between women and men might play a part in the disease. Who is more likely to develop scleroderma? Anyone can get scleroderma, but certain factors may make you more likely to develop it: Your sex. Scleroderma is more common in women than in men. Your age. The disease usually appears between the ages of 30 and 50. Your race. Scleroderma can affect people of all races and ethnic groups, but the disease can affect African Americans more severely. What are the symptoms of scleroderma? The symptoms of scleroderma a

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This information is for general education and is not medical advice. Always talk to a licensed U.S. clinician about your situation, medications, or treatment decisions.