Risk of Acute Kidney Injury inEnteritis Compared WithEnteritis: A Retrospective Cohort Study
Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine
Abstract Background andare leading causes of bacterial gastroenteritis worldwide, yet their comparative impact on acute kidney injury (AKI) remains unexplored. s1 Methods We conducted a retrospective cohort study of adults (≥18 years) hospitalized with community-acquired bacterial gastroenteritis at a tertiary center in South Korea (2018–2025). The primary outcome was AKI incidence. Multivariable logistic regression assessed associations between pathogen type (,, or Others, includingor) and AKI risk (reference:). Secondary outcomes included postdischarge kidney outcomes (acute kidney disease [AKD], incident chronic kidney disease [CKD], and CKD progression). s2 Results Among 232 patients (n = 139,n = 55, and Others n = 38), AKI incidence differed significantly across groups (26.6%, 70.9%, and 31.6%, respectively;< .001), with 42% ofpatients developing AKI stages 2 and 3.enteritis was independently associated with higher AKI risk than(odds ratio 3.19, 95% confidence interval [CI] 1.23–8.30).patients had 46% longer hospital stays (median 8 vs 5 days). In-hospital AKI was associated with postdischarge composite kidney outcome (hazard ratio 3.17, 95% CI 1.02–9.83), particularly during the AKD window (7–90 days postdischarge). Notably, 17% of patients who recovered from AKI before discharge subsequently developed AKD or CKD. s3 Conclusions In this retrospective study, hospitalized patients withenteritis had a higher risk of AKI than those with; furthermore, those with in-hospital
Abstract
Abstract Background andare leading causes of bacterial gastroenteritis worldwide, yet their comparative impact on acute kidney injury (AKI) remains unexplored. s1 Methods We conducted a retrospective cohort study of adults (≥18 years) hospitalized with community-acquired bacterial gastroenteritis at a tertiary center in South Korea (2018–2025). The primary outcome was AKI incidence. Multivariable logistic regression assessed associations between pathogen type (,, or Others, includingor) and AKI risk (reference:). Secondary outcomes included postdischarge kidney outcomes (acute kidney disease [AKD], incident chronic kidney disease [CKD], and CKD progression). s2 Results Among 232 patients (n = 139,n = 55, and Others n = 38), AKI incidence differed significantly across groups (26.6%, 70.9%, and 31.6%, respectively;< .001), with 42% ofpatients developing AKI stages 2 and 3.enteritis was independently associated with higher AKI risk than(odds ratio 3.19, 95% confidence interval [CI] 1.23–8.30).patients had 46% longer hospital stays (median 8 vs 5 days). In-hospital AKI was associated with postdischarge composite kidney outcome (hazard ratio 3.17, 95% CI 1.02–9.83), particularly during the AKD window (7–90 days postdischarge). Notably, 17% of patients who recovered from AKI before discharge subsequently developed AKD or CKD. s3 Conclusions In this retrospective study, hospitalized patients withenteritis had a higher risk of AKI than those with; furthermore, those with in-hospital AKI from any cause were more likely to have adverse short-to-intermediate–term postdischarge kidney abnormalities. These findings support pathogen-specific risk stratification and the need for postdischarge monitoring of patients who develop in-hospital AKI. s4 In this retrospective cohort of 232 hospitalized adults with bacterial gastroenteritis,enteritis was associated with a 3.2-fold higher AKI risk than, and 17% of patients recovering from AKI subsequently developed acute kidney disease or chronic kidney disease, suggesting the potential benefit of continued postdischarge kidney monitoring. teaser