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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Source: MedlinePlus Health Topics, U.S. National Library of Medicine

Last synced 8/4/2026Status: primary verified

What is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)? Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. Another name for it is chronic fatigue syndrome (CFS). ME/CFS can often make you unable to do your usual activities. Sometimes you may not even be able to get out of bed. What causes myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)? Researchers don't yet know what causes ME/CFS. There may be more than one potential cause. It is also possible that two or more triggers might work together to cause the illness. Researchers are studying many possible causes, including: Infections Immune system changes Physical or emotional stress Changes in the way cells in the body get their energy Genetics; the illness can sometimes run in families Who is more likely to develop myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)? Anyone can get ME/CFS, but it is most common in people between 40 and 60 years old. Adult women are more likely to develop it than adult men. What are the symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)? The primary, or core, symptoms of ME/CFS are: Not being able to do activities that you used to do before the illness, along with severe fatigue. The fatigue must last six months or longer, and it is not improved by rest. Post-exertional malaise (PEM), which means that your symptoms get worse after any physical or mental activity. Sleep problems . Along with the primary symptoms, to be diagnosed with ME/CFS, you need to have one or both of these symptoms: Problems with thinking and memory . Worsening of symptoms while standing or sitting upright. This is called orthostatic intolerance. It can cause you to feel lightheaded, dizzy , weak, or faint while standing or sitting up. Some of the other symptoms that ME/CFS can cause include: Pain , including muscle pain, joint pain, and headaches Sore throat Tender lymph nodes (glands) in

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