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Fifth Disease

Source: MedlinePlus Health Topics, U.S. National Library of Medicine

Last synced 8/14/2026Status: primary verified

What is fifth disease? Fifth disease, also called erythema infectiosum, is a viral infection caused by parvovirus B19. This virus only infects people; it's not the same type of parvovirus that dogs and cats can get. Fifth disease mostly affects children. It often causes a bright red rash on their cheeks (sometimes called a "slapped cheek" rash). In the United States, parvovirus B19 infections are more common in late winter, spring, and early summer. There are usually minor outbreaks of fifth disease about every 3 to 4 years. What causes fifth disease? Parvovirus B19, which causes fifth disease, can spread from person to person: Through respiratory droplets, such as saliva (spit), sputum, or nasal mucus. The droplets can spread when: Someone who has the virus coughs and sneezes You touch an item that has the virus on it Through blood or blood products From a pregnant parent to the baby during pregnancy You are most contagious early in your infection, when you usually only have a fever or cold-like symptoms. You are not likely to be contagious after you get later symptoms such as a rash and joint pain. What are the symptoms of fifth disease? About 2 out of 10 people who get a B19 parvovirus infection will have no symptoms. But most people will get the symptoms of fifth disease, which are usually mild and can include: Fever Headache Cough Sore throat Rashes Joint pain The "slapped cheek" rash is more common in children. They usually get the rash a few days after they first have other symptoms. The rash can then spread to the arms, legs, chest, back, and buttocks. Adults who get fifth disease might also have joint pain and swelling (called polyarthropathy syndrome). Sometimes the infection can cause serious health complications affecting the nerves, joints, or blood system. This is more likely to happen if you are pregnant, have a blood disorder such as anemia , or a weakened immune system . Because of these risks to you and some possible risks to your baby, contact you

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This information is for general education and is not medical advice. Always talk to a licensed U.S. clinician about your situation, medications, or treatment decisions.