Fatigue

Source: MedlinePlus Health Topics, U.S. National Library of Medicine

Last synced 8/14/2026Status: primary verified

What is fatigue? Fatigue is a feeling of weariness, tiredness, or lack of energy. It can interfere with your usual daily activities. Fatigue can be a normal response to physical activity, emotional stress , boredom, or lack of sleep. But sometimes it can be a sign of a mental or physical condition. If you have been feeling tired for weeks, contact your health care provider. They can help you find out what's causing your fatigue and recommend ways to relieve it. What causes fatigue? Fatigue itself is not a disease; it's a symptom. It can have many different causes, including pregnancy and various medical problems, treatments, and lifestyle habits such as: Medical problems: Chronic (long-lasting) diseases such as diabetes , COPD (chronic obstructive pulmonary disease), and heart , liver , kidney and thyroid diseases Untreated pain and diseases like fibromyalgia Anemia Infections Parkinson's disease Sleep apnea and other sleep disorders Recent stroke Mental disorders such as depression and anxiety Treatments: Cancer treatments such as chemotherapy , radiation , and bone marrow transplants Recovering from major surgery Taking certain medicines, such as antidepressants , antihistamines, and medicines for nausea and pain Lifestyle habits: Not getting enough sleep Staying up too late Drinking too much alcohol Substance use Having too much caffeine (which can keep you from getting a good night's sleep) Getting too little or too much exercise Overwhelming fatigue is part of a disorder called myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The fatigue caused by this disorder is different from a tired feeling that goes away after you rest. Instead, the fatigue in ME/CFS lasts a long time, does not get better with rest, and limits your ability to do ordinary daily activities. What can I do to manage fatigue? If you've had fatigue that does not get better after several weeks, call your provider. They will ask questions about your sleep, daily activities, appetite, a

Educational only

This information is for general education and is not medical advice. Always talk to a licensed U.S. clinician about your situation, medications, or treatment decisions.