Evaluation of Anxiety and Depression in Patients with Chronic Rhinosinusitis with Nasal Polyps
Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine
Purpose Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammation of the sinuses accompanied by the formation of obstructive nasal polyps, which may lead to symptoms of common mental disorders, including anxiety and depression, as a result of long-term discomfort. This study aimed to investigate the associations of severe CRSwNP, with anxiety and depression. s2001 Methods Adult patients with severe primary diffuse CRSwNP scheduled to undergo sinus surgery and healthy control participants were prospectively enrolled. Clinical data were collected and the Sinonasal Outcome Test-22 (SNOT-22), Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI) were used to evaluate quality of life. s2002 Results Ninety-six patients with CRSwNP and 40 controls were enrolled in this study. Patients with CRSwNP exhibited significantly higher BAI scores than controls. However, BDI-II scores were not significantly different. Among the patients with CRSwNP, 32.3% exhibited possible anxiety, defined as a BAI score >7. Comorbid asthma, SNOT-22 score, and blood eosinophil percentage were significant factors associated with anxiety in patients with CRSwNP in univariate logistic regression analysis and comorbid asthma and SNOT-22 remained statistically significant in multivariable analysis. An SNOT-22 score > 57 was the optimal cutoff value for identifying patients with possible anxiety. s2003 Conclusion A significant proportion of patients with CRSwNP exhibited anxi
Abstract
Purpose Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammation of the sinuses accompanied by the formation of obstructive nasal polyps, which may lead to symptoms of common mental disorders, including anxiety and depression, as a result of long-term discomfort. This study aimed to investigate the associations of severe CRSwNP, with anxiety and depression. s2001 Methods Adult patients with severe primary diffuse CRSwNP scheduled to undergo sinus surgery and healthy control participants were prospectively enrolled. Clinical data were collected and the Sinonasal Outcome Test-22 (SNOT-22), Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI) were used to evaluate quality of life. s2002 Results Ninety-six patients with CRSwNP and 40 controls were enrolled in this study. Patients with CRSwNP exhibited significantly higher BAI scores than controls. However, BDI-II scores were not significantly different. Among the patients with CRSwNP, 32.3% exhibited possible anxiety, defined as a BAI score >7. Comorbid asthma, SNOT-22 score, and blood eosinophil percentage were significant factors associated with anxiety in patients with CRSwNP in univariate logistic regression analysis and comorbid asthma and SNOT-22 remained statistically significant in multivariable analysis. An SNOT-22 score > 57 was the optimal cutoff value for identifying patients with possible anxiety. s2003 Conclusion A significant proportion of patients with CRSwNP exhibited anxiety symptoms. Comorbid asthma, SNOT-22 score, and blood eosinophil percentage were significant factors associated with the presence of anxiety. These findings emphasize the importance of screening for psychological symptoms and potentially integrating psychological assessments and interventions in the care of high-risk patients. s2004 Plain Language Summary Patients with Chronic rhinosinusitis with nasal polyps (CRSwNP) exhibited significantly higher Beck Anxiety Inventory (BAI) scores than the controls. However, Beck Depression Inventory-II scores were not significantly different between the groups. A significant proportion (32.3%) of patients with CRSwNP exhibited anxiety, defined as a BAI score >7. Comorbid asthma, Sinonasal Outcome Test-22 score, and blood eosinophil percentage were significant factors associated with the presence of anxiety. plain-language-summary