[Effectiveness of therapeutic strategies based on dietary patterns on cardiovascular and hepatic markers in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) ‒ A systematic review of clinical trials].
Source: PubMed, NCBI / U.S. National Library of Medicine
metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the leading causes of global liver morbidity and liver transplantation. In this context, dietary patterns emerge as a key therapeutic tool for modulating the cardiometabolic and hepatic profiles in this condition. to evaluate the effectiveness of therapeutic approaches based on dietary patterns on the cardiometabolic and hepatic factors in adult individuals diagnosed with MASLD. a comprehensive search was conducted in PubMed, EMBASE, and Web of Science from inception to October 1, 2025. Eligibility criteria were restricted to randomized controlled trials (RCTs). Furthermore, the Risk of Bias 2 (RoB-2) tool was applied for the assessment of bias. a total of 11 RCTs were selected, representing a total population of 737 adult participants. The effectiveness of Mediterranean Diet (MD) prescriptions was evaluated in 36.4 % (n = 4) of the studies, while 27.3 % (n = 3) assessed time-restricted eating (TRE) patterns. The evidence analyzed suggests that metabolic improvements were concentrated in dietary patterns such as the MD, with the DASH diet reporting marked cardiovascular effects. Our results suggest that these patterns not only act on hepatic fat likewise, mitigate concomitant cardiovascular risk factors, with moderate evidence particularly evident in relation to hepatic enzymes. dietary patterns characterized by a high intake of fiber, polyphenols, and polyunsaturated fatty acids, such as the MD and DA
Abstract
metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the leading causes of global liver morbidity and liver transplantation. In this context, dietary patterns emerge as a key therapeutic tool for modulating the cardiometabolic and hepatic profiles in this condition. to evaluate the effectiveness of therapeutic approaches based on dietary patterns on the cardiometabolic and hepatic factors in adult individuals diagnosed with MASLD. a comprehensive search was conducted in PubMed, EMBASE, and Web of Science from inception to October 1, 2025. Eligibility criteria were restricted to randomized controlled trials (RCTs). Furthermore, the Risk of Bias 2 (RoB-2) tool was applied for the assessment of bias. a total of 11 RCTs were selected, representing a total population of 737 adult participants. The effectiveness of Mediterranean Diet (MD) prescriptions was evaluated in 36.4 % (n = 4) of the studies, while 27.3 % (n = 3) assessed time-restricted eating (TRE) patterns. The evidence analyzed suggests that metabolic improvements were concentrated in dietary patterns such as the MD, with the DASH diet reporting marked cardiovascular effects. Our results suggest that these patterns not only act on hepatic fat likewise, mitigate concomitant cardiovascular risk factors, with moderate evidence particularly evident in relation to hepatic enzymes. dietary patterns characterized by a high intake of fiber, polyphenols, and polyunsaturated fatty acids, such as the MD and DASH, demonstrate high effectiveness in the treatment of MASLD. Future dietary interventions should compare approaches involving additional olive oil supplementation or specific combinations of polyunsaturated fatty acids.