Early-pregnancy fasting blood glucose and subsequent GDM define four distinct risk groups for adverse pregnancy outcomes: a cohort study of 15,245 women

Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine

Objective To investigate the associations between a four-group classification based on early-pregnancy FBG and subsequent GDM status and maternal and neonatal outcomes, and to characterize the FBG-HDP dose-response relationship. Methods This retrospective cohort study included 15,245 women with singleton pregnancies. Participants were categorized into four groups based on early-pregnancy FBG ( 0.05). Sensitivity analyses using alternative FBG cutoffs (≥5.3 and ≥5.6 mmol/L) confirmed the robustness of these findings. Conclusions The four-group classification based on early-pregnancy FBG and subsequent GDM status may be useful for stratifying the risk of adverse pregnancy outcomes. The observed inflection point warrants further investigation. These findings support the potential value of early-pregnancy glycemic assessment in refining risk characterization for pregnant women.