Library
PubMed Central Open Access
research article
Professional
Open access

Early functional deficits following first‐time acute lateral ankle sprain: A multidimensional assessment framework with clinically relevant cut‐off values

Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine

Journal of Experimental OrthopaedicsLast synced 8/29/2026Status: syncedPMID: 42662975 pmidDOI: 10.1002/jeo2.70892

Abstract Purpose Lateral ankle sprain (LAS) is one of the most common musculoskeletal injuries associated with sensorimotor impairments that increase the risk of reinjury and chronic ankle instability. Early clinical assessment after acute LAS is often symptom‐guided rather than based on objective functional testing. This study aimed to identify the most sensitive functional impairments within the first weeks after injury and to determine cut‐off values that support structured clinical assessment. jeo270892-sec-0010 Methods In this cross‐sectional matched case‐control analysis, 36 individuals (14–41 years) with MRI‐confirmed first‐time acute LAS were compared to 36 matched healthy controls. Patients (recruiting 01/22‐09/24) were assessed 2–3 weeks post‐injury using patient‐reported outcomes, postural control, strength, range of motion (ROM), gait/running kinematics and jump performance. Between‐group differences were analysed usingtests or Statistical Parametric Mapping. Receiver operating characteristic analyses were used to determine diagnostic cut‐off values. It was hypothesized that individuals with acute first‐time LAS would demonstrate clinically relevant deficits across functional domains compared with healthy controls, and that these parameters would allow the derivation of clinically useful cut‐off values. jeo270892-sec-0020 Results Individuals with LAS demonstrated substantial impairments across several domains. The most discriminative parameters were Foot and Ankle

Abstract

Abstract Purpose Lateral ankle sprain (LAS) is one of the most common musculoskeletal injuries associated with sensorimotor impairments that increase the risk of reinjury and chronic ankle instability. Early clinical assessment after acute LAS is often symptom‐guided rather than based on objective functional testing. This study aimed to identify the most sensitive functional impairments within the first weeks after injury and to determine cut‐off values that support structured clinical assessment. jeo270892-sec-0010 Methods In this cross‐sectional matched case‐control analysis, 36 individuals (14–41 years) with MRI‐confirmed first‐time acute LAS were compared to 36 matched healthy controls. Patients (recruiting 01/22‐09/24) were assessed 2–3 weeks post‐injury using patient‐reported outcomes, postural control, strength, range of motion (ROM), gait/running kinematics and jump performance. Between‐group differences were analysed usingtests or Statistical Parametric Mapping. Receiver operating characteristic analyses were used to determine diagnostic cut‐off values. It was hypothesized that individuals with acute first‐time LAS would demonstrate clinically relevant deficits across functional domains compared with healthy controls, and that these parameters would allow the derivation of clinically useful cut‐off values. jeo270892-sec-0020 Results Individuals with LAS demonstrated substantial impairments across several domains. The most discriminative parameters were Foot and Ankle Ability Measure (FAAM) Sport (effect size [ES] −4.09, cut‐off 0.23 s) (jump performance). These measures formed a minimal multidimensional assessment. jeo270892-sec-0030 Conclusion These parameters and cut‐off values enable objective, multidimensional assessment in the early phase after acute LAS and may facilitate impairment‐based rehabilitation beyond symptom‐guided evaluation. jeo270892-sec-0040 Level of Evidence Level III, cross‐sectional matched pair‐study. jeo270892-sec-0050 Early functional deficits following first‐time acute lateral ankle sprain: A multidimensional assessment framework with clinically relevant cut‐off values. graphical

Educational only
This information is for general education and is not medical advice. Always talk to a licensed U.S. clinician about your situation, medications, or treatment decisions.