Disrupted Functional Network Organization in Crohn's Disease: Interoceptive Alterations Linked to Anxiety
Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine
ABSTRACT Background and Aims How Crohn's disease alters large‐scale brain network organization and interacts with affective symptoms remains poorly understood. We aimed to characterize disease‐related disruptions in functional topology, rich‐club organization, and hierarchical gradients, and to determine their associations with disease activity and anxiety. cns71113-sec-0001 Methods Ninety‐seven Crohn's disease patients and 64 healthy controls underwent resting‐state fMRI. Graph‐theoretical metrics, rich‐club analysis, functional gradients, and spectral dynamic causal modeling were applied to assess network properties, hierarchical architecture, and effective connectivity. Associations with the Crohn's Disease Activity Index and anxiety were examined via linear regression. cns71113-sec-0002 Results Crohn's disease patients showed widespread network disruptions modestly linked to disease activity, including reduced global and local efficiency, impaired rich‐club connectivity, and compressed sensorimotor gradients. Decreased degree centrality in the insula, thalamus, and postcentral gyrus was accompanied by altered hierarchical organization and effective connectivity. Spectral dynamic causal modeling revealed anxiety‐related modulation of insular excitation and thalamo‐putaminal pathways. cns71113-sec-0003 Conclusions Crohn's disease involves widespread functional network disruption and reorganization, particularly in interoceptive regions supporting sensory and emotional proce
Abstract
ABSTRACT Background and Aims How Crohn's disease alters large‐scale brain network organization and interacts with affective symptoms remains poorly understood. We aimed to characterize disease‐related disruptions in functional topology, rich‐club organization, and hierarchical gradients, and to determine their associations with disease activity and anxiety. cns71113-sec-0001 Methods Ninety‐seven Crohn's disease patients and 64 healthy controls underwent resting‐state fMRI. Graph‐theoretical metrics, rich‐club analysis, functional gradients, and spectral dynamic causal modeling were applied to assess network properties, hierarchical architecture, and effective connectivity. Associations with the Crohn's Disease Activity Index and anxiety were examined via linear regression. cns71113-sec-0002 Results Crohn's disease patients showed widespread network disruptions modestly linked to disease activity, including reduced global and local efficiency, impaired rich‐club connectivity, and compressed sensorimotor gradients. Decreased degree centrality in the insula, thalamus, and postcentral gyrus was accompanied by altered hierarchical organization and effective connectivity. Spectral dynamic causal modeling revealed anxiety‐related modulation of insular excitation and thalamo‐putaminal pathways. cns71113-sec-0003 Conclusions Crohn's disease involves widespread functional network disruption and reorganization, particularly in interoceptive regions supporting sensory and emotional processing. Anxiety modulates core limbic circuitry, highlighting the interplay between disease activity and affective symptoms in shaping brain network. cns71113-sec-0004 Crohn's disease shows widespread disruption and reorganization of functional brain networks, with altered activity in core interoceptive regions involved in sensory and emotional processing. Emotional disturbances modulate brain network dynamics, providing insight into neural mechanisms linking disease activity and affective symptoms. graphical