Contributions of whole-genome sequencing to the epidemiological monitoring ofspp. in France.

Source: PubMed, NCBI / U.S. National Library of Medicine

Next-generation sequencing techniques have revolutionized the epidemiology and understanding ofspp. infections. In this study, we present the results of a next-generation sequencing (NGS) analysis conducted in 2024 on 2,360r spp. strains isolated in France, including 1,959358, and 43strains. We describe the diversity of circulating strains and provide an overview of the main mechanisms of antibiotic resistance. We identified a variety of resistance mechanisms, particularly for resistance to group A penicillins. Notably, we identified a novel promoter upstream of the gene encoding a beta-lactamase. Using source attribution markers forandwe identified poultry as the main vector for infections by these two species. However, ruminant meat accounts for a significant proportion ofinfections in France. This study demonstrates how a sequencing strategy can generate large-scale and high-resolution data for understandingspp. infections.