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Colorectal Cancer

Source: MedlinePlus Health Topics, U.S. National Library of Medicine

Last synced 8/10/2026Status: primary verified

What is colorectal cancer? Colorectal cancer is cancer that develops in the tissues of the colon or rectum. Your colon and rectum are part of your digestive system: Your colon is the first and longest part of your large intestine. It absorbs water and some nutrients from foods. It also changes the leftover waste products into stool (poop). Your rectum is the lower part of your large intestine. It's where your body stores stool. Cancer that begins in the colon is called colon cancer, and cancer that begins in the rectum is called rectal cancer. Cancer that affects either of these parts may also be called colorectal cancer. What causes colorectal cancer? Colorectal cancer happens when there are changes in your genetic material (DNA) . These changes are also called mutations or variants. Often, the genetic changes that lead to colorectal cancer happen during your lifetime and the exact cause is unknown. But certain genetic changes that raise your risk for colorectal cancer are inherited, meaning that you are born with them. Besides genetics, other factors, including your lifestyle and the environment, can affect your risk of colorectal cancer. Who is more likely to develop colorectal cancer? Anyone can get colorectal cancer, but certain factors make you more likely to develop it: Being older; your risk of getting colorectal cancer increases as you age. Having a personal or family history of colorectal cancer. Having a history of adenomas. Adenomas are colorectal polyps (growths) that look abnormal under a microscope or are 1 centimeter or larger. Adenomas are not cancer, but they can sometimes turn into cancer over time. Having a genetic syndrome such as familial adenomatous polyposis (FAP) or Lynch syndrome (hereditary non-polyposis colorectal cancer). Having chronic ulcerative colitis or Crohn disease for 8 years or more. Having three or more alcoholic drinks per day. Smoking cigarettes . Being Black; Black people have an increased risk of colorectal cancer and death

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This information is for general education and is not medical advice. Always talk to a licensed U.S. clinician about your situation, medications, or treatment decisions.