Cerebral small vessel disease and cognition in older adults across the neurodegenerative spectrum: insights from the COMPASS‐ND study
Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine
Abstract INTRODUCTION Imaging‐based cerebral small vessel disease (CSVD) summary scores quantify CSVD burden. This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegenerative diseases and cognitive profiles. alz71546-sec-0010 METHODS Baseline data from 958 Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS‐ND) study participants were analyzed (19.4% cognitively normal, 14.9% subjective cognitive decline, 40.3% mild cognitive impairment, 25.4% dementia). MRI markers of cerebral vascular injury (lacunes, microbleeds, white matter hyperintensities [WMHs], and enlarged perivascular spaces) were visually rated, and a cumulative CSVD score was generated. Cognition was measured using the Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating‐Sum of Boxes (CDR‐SB), and a composite neuropsychological battery test‐score. alz71546-sec-0020 RESULTS Higher CSVD scores were associated with greater Hachinski ischemic scores, poorer MoCA performance, worse CDR‐SB, and lower composite‐scores. Associations were strongest for cognitive domains of executive function, attention, and learning. alz71546-sec-0030 DISCUSSION CSVD burden may further contribute to poorer cognition across neurodegenerative conditions and cognitive profiles. alz71546-sec-0040 Highlights CSVD summary scores were evaluated using MRI. Greater CSVD burden was associated with poorer global cognition and function. CSVD was most associated wit
Abstract
Abstract INTRODUCTION Imaging‐based cerebral small vessel disease (CSVD) summary scores quantify CSVD burden. This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegenerative diseases and cognitive profiles. alz71546-sec-0010 METHODS Baseline data from 958 Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS‐ND) study participants were analyzed (19.4% cognitively normal, 14.9% subjective cognitive decline, 40.3% mild cognitive impairment, 25.4% dementia). MRI markers of cerebral vascular injury (lacunes, microbleeds, white matter hyperintensities [WMHs], and enlarged perivascular spaces) were visually rated, and a cumulative CSVD score was generated. Cognition was measured using the Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating‐Sum of Boxes (CDR‐SB), and a composite neuropsychological battery test‐score. alz71546-sec-0020 RESULTS Higher CSVD scores were associated with greater Hachinski ischemic scores, poorer MoCA performance, worse CDR‐SB, and lower composite‐scores. Associations were strongest for cognitive domains of executive function, attention, and learning. alz71546-sec-0030 DISCUSSION CSVD burden may further contribute to poorer cognition across neurodegenerative conditions and cognitive profiles. alz71546-sec-0040 Highlights CSVD summary scores were evaluated using MRI. Greater CSVD burden was associated with poorer global cognition and function. CSVD was most associated with poorer executive function, attention, and learning. WMHs were the individual marker most tied to cognition. CSVD summary scores may help assess vascular contributions to cognitive decline. bullet alz71546-list-0001 highlights