Catalytic Amidation of Carboxylic Acids Using-Aminophenylboronic Acids

Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine

ACS Organic & Inorganic AuLast synced 8/9/2026Status: syncedPMID: 42569138 pmidDOI: 10.1021/acsorginorgau.6c00021

-Substituted boronic acids have demonstrated significant potential as catalysts for direct amidation reactions, providing a sustainable alternative to conventional coupling reagents. We report the screening of-functionalized arylboronic acids, including four literature benchmarks, as catalysts for the direct condensation of amines and carboxylic acids. The commercially available-aminophenylboronic acids, specifically (2-(piperidin-1-yl)phenyl)boronic acid (2-PPBA), emerge as the optimal catalyst, providing amides from a range of carboxylic acids and amines. http://www.w3.org/1999/xlink float portrait gg6c00021_0009.jpg graphical http://www.w3.org/1999/xlink tgr1 not-for-print float portrait gg6c00021_0007.jpg toc-graphic

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