Can an antibiotic trigger a heart attack? Kounis syndrome induced by intraoperative amoxicillin allergy: a case report.

Source: PubMed, NCBI / U.S. National Library of Medicine

Revista espanola de anestesiologia y reanimacionBernaola M, Gago A, Umpiérrez A, et al.Published 2/12/2026Last synced 6/6/2026Status: syncedPMID: 41690472DOI: 10.1016/j.redare.2026.502035

Kounis syndrome (KS) is an acute coronary syndrome triggered by mast cell degranulation in response to allergic or hypersensitivity reactions. Drug-induced KS, particularly due to antibiotics like amoxicillin, represents a severe and potentially life-threatening condition. This review aims to analyze the pathophysiology, clinical manifestations, diagnostic approaches, and management strategies of KS induced by amoxicillin allergy, with a focus on recent literature and emerging therapeutic insights.

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