Bicaudal‑C1 in Cancer: Molecular Mechanisms and Therapeutic Strategies Integrating Chinese and Western Medicine

Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine

Abstract Bicaudal-C homolog 1 (BICC1) is an essential RNA-binding protein that plays a significant role in cellular signaling and gene expression regulation. Recent research has linked the BICC1 gene to the initiation and advancement of tumors. Current investigations primarily aim to elucidate its structural characteristics and functional roles, while its precise involvement in tumorigenesis and its viability as a therapeutic target are still being explored. This review delves into the structure and functions of BICC1, emphasizing its participation in tumor cell growth, programmed cell death, epithelial-mesenchymal transition (EMT), blood vessel formation, maintenance of stem cells, and chemoresistance. Furthermore, it examines progress in developing drugs that target BICC1 for cancer therapy and evaluates the potential advantages of traditional Chinese medicine in mediating anti-tumor effects through BICC1 modulation, offering perspectives for future targeted treatment strategies.