Beyond associations: Navigating the safety of non-steroidal anti-inflammatory drugs (NSAIDs) in early pregnancy

Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine

Pain and fever in pregnancy require treatment, but fetal safety concerns complicate analgesic choice. A recentstudy presents new evidence on the safety of first-trimester NSAID use and congenital malformation risk, but interpreting findings across studies is challenging. teaser In this Perspective, Kenneth Man and Andrew Yuen highlight a recent PLOS Medicine study that presents new evidence on the safety of first-trimester NSAID use and congenital malformation risk, but discuss why interpreting findings across studies is challenging. toc