Atherosclerosis

Source: MedlinePlus Health Topics, U.S. National Library of Medicine

Last synced 8/9/2026Status: primary verified

What is atherosclerosis? Atherosclerosis is a condition in which plaque builds up inside your arteries. Plaque is a sticky substance made up of cholesterol , fat, blood cells, calcium, and other substances found in the blood. Over time, plaque hardens and causes your arteries to narrow. That limits the flow of oxygen-rich blood to your body. Some people may confuse atherosclerosis and arteriosclerosis, but they are not the same thing: Arteriosclerosis is hardening of the arteries, which means that the arteries thicken and become less flexible. It can have several different causes. Atherosclerosis , which develops from plaque buildup, is a common type of arteriosclerosis. Atherosclerosis can affect most of the arteries in the body. It has different names, based on which arteries are affected: Coronary artery disease (CAD) is plaque buildup in the arteries of your heart. Peripheral artery disease (PAD) is plaque buildup in the arteries that carry blood away from the heart to other parts of the body. It most often affects the arteries of your legs, but it can also affect the arteries of your arms or pelvis. Carotid artery disease is plaque buildup in the neck arteries. It reduces blood flow to the brain. Renal artery stenosis is plaque buildup in the arteries that supply blood to your kidneys. Vertebral artery disease is plaque buildup in the arteries that supply blood to the back of your brain. Mesenteric artery ischemia is plaque buildup in the arteries that supply your intestines with blood. What causes atherosclerosis? Plaque often starts to build up during childhood and gets worse with age. The exact cause is unknown, but researchers believe that this buildup happens when there is damage to the arteries. This damage may be caused by unhealthy lifestyle habits, medical conditions, and your genes. Who is more likely to develop atherosclerosis? You may be more likely to develop atherosclerosis if you: Have certain medical conditions, including: High blood pressure Hi

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This information is for general education and is not medical advice. Always talk to a licensed U.S. clinician about your situation, medications, or treatment decisions.