Association Between Atherogenic Index of Plasma and Patients With Acute Ischemic Stroke Receiving Intravenous Thrombolysis: A Retrospective Cohort, Multi-Center Study.
Source: PubMed, NCBI / U.S. National Library of Medicine
There are inherent risks associated with intravenous thrombolysis (IVT) therapy in patients with acute ischemic stroke (AIS). The atherogenic index of plasma (AIP), defined as log (triglyceride [TG]/high-density lipoprotein cholesterol [HDL-C]), has recently been associated with the prognosis. We aimed to gauge AIP prognostic value in AIS patients receiving IVT. We retrospectively collected data from 183 AIS patients who underwent IVT. We grouped modified Rankin Scale scores of 0-2 and 3-6 as good and poor outcomes at 1 year, respectively. Multivariate logistic regression, receiver operating characteristic (ROC) curve and restricted cubic spline (RCS) analyses were used to investigate the underlying link between the AIP and 1-year functional outcomes. In this study, 67 patients (36.6%) exhibited poor 1-year outcomes. An optimal AIP cut-off of 0.188 was used to divide the patients into low and high AIP levels. Our results showed that continuous AIP (odds ratio [OR] = 25.10, 95% confidence interval [CI]: 4.86-129.68,< 0.001) was associated with poor 1-year outcome; when AIP was as a categorical variable, OR (95% CI) for the prognosis in the high AIP group was 27.86 (9.33-83.25) compared with the low AIP group. ROC analyses revealed that the area under the ROC curve for the AIP was 0.694 (0.603-0.785), with a sensitivity of 87.1% and a specificity of 61.2%. In the fully adjusted RCS, we found a positive but non-linear trend between the AIP and prognosis. High AIP may offer poten
Abstract
There are inherent risks associated with intravenous thrombolysis (IVT) therapy in patients with acute ischemic stroke (AIS). The atherogenic index of plasma (AIP), defined as log (triglyceride [TG]/high-density lipoprotein cholesterol [HDL-C]), has recently been associated with the prognosis. We aimed to gauge AIP prognostic value in AIS patients receiving IVT. We retrospectively collected data from 183 AIS patients who underwent IVT. We grouped modified Rankin Scale scores of 0-2 and 3-6 as good and poor outcomes at 1 year, respectively. Multivariate logistic regression, receiver operating characteristic (ROC) curve and restricted cubic spline (RCS) analyses were used to investigate the underlying link between the AIP and 1-year functional outcomes. In this study, 67 patients (36.6%) exhibited poor 1-year outcomes. An optimal AIP cut-off of 0.188 was used to divide the patients into low and high AIP levels. Our results showed that continuous AIP (odds ratio [OR] = 25.10, 95% confidence interval [CI]: 4.86-129.68,< 0.001) was associated with poor 1-year outcome; when AIP was as a categorical variable, OR (95% CI) for the prognosis in the high AIP group was 27.86 (9.33-83.25) compared with the low AIP group. ROC analyses revealed that the area under the ROC curve for the AIP was 0.694 (0.603-0.785), with a sensitivity of 87.1% and a specificity of 61.2%. In the fully adjusted RCS, we found a positive but non-linear trend between the AIP and prognosis. High AIP may offer potential value as a novel target for predicting 1-year outcomes in patients receiving IVT.