Anterior commissure involvement in Marchiafava-Bignami disease: MRI findings.

Source: PubMed, NCBI / U.S. National Library of Medicine

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyChen Ying, Lu Yin, Chen JiePublished 5/25/2026Last synced 5/27/2026Status: syncedPMID: 42183947DOI: 10.1007/s10072-026-09126-w

A 52-year-old man with a 30-year history of chronic alcohol abuse presented withseizures and progressive cognitive decline. Brain MRI demonstrated symmetricdiffusion-weighted hyperintensities involving the genu, body, and splenium of thecorpus callosum, extending to the anterior commissure, with corresponding restricteddiffusion on the apparent diffusion coefficient map. These findings were consistent withMarchiafava-Bignami disease, reflecting a toxic-metabolic demyelinating processassociated with chronic alcohol exposure.

Educational only

This information is for general education and is not medical advice. Always talk to a licensed U.S. clinician about your situation, medications, or treatment decisions.