Adherence to an antioxidant diet is associated with reduced risk of epilepsy among American adults - NHANES 2013-2018.
Source: PubMed, NCBI / U.S. National Library of Medicine
Background: oxidative stress is correlated with epilepsy. Oxidative Balance Scores (OBS) serve as a systematic approach for evaluating oxidative stress in relation to dietary and lifestyle factors. The relationship between OBS and epilepsy is unclear. An investigation of the relationship between OBS and epilepsy was conducted in this study. Methods: in this cross-sectional study, we employed weighted logistic regression and conducted sensitivity analysis to examine the correlation between OBS and epilepsy. Additionally, we performed subgroup analysis and an interaction test to ascertain the consistency of this relationship across different demographic groups. Results: 11,910 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2018 were included in this study. The results indicated a statistically significant inverse relationship between OBS and the prevalence of epilepsy [0.95 (0.92, 0.99)]. Furthermore, when OBS was converted into a quartile variable, individuals with OBS values greater than 25 had an adjusted OR of 0.47 compared to the lowest (95 % CI: 0.24, 0.92). Specifically, dietary OBS showed a consistent negative correlation with epilepsy risk across all models, while lifestyle OBS did not exhibit an association. The results of our study revealed a notable interaction between serum UA levels and race and diabetes (p < 0.05 for interaction). Conclusions: the study revealed a noteworthy inverse correlation between O
Abstract
Background: oxidative stress is correlated with epilepsy. Oxidative Balance Scores (OBS) serve as a systematic approach for evaluating oxidative stress in relation to dietary and lifestyle factors. The relationship between OBS and epilepsy is unclear. An investigation of the relationship between OBS and epilepsy was conducted in this study. Methods: in this cross-sectional study, we employed weighted logistic regression and conducted sensitivity analysis to examine the correlation between OBS and epilepsy. Additionally, we performed subgroup analysis and an interaction test to ascertain the consistency of this relationship across different demographic groups. Results: 11,910 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2018 were included in this study. The results indicated a statistically significant inverse relationship between OBS and the prevalence of epilepsy [0.95 (0.92, 0.99)]. Furthermore, when OBS was converted into a quartile variable, individuals with OBS values greater than 25 had an adjusted OR of 0.47 compared to the lowest (95 % CI: 0.24, 0.92). Specifically, dietary OBS showed a consistent negative correlation with epilepsy risk across all models, while lifestyle OBS did not exhibit an association. The results of our study revealed a notable interaction between serum UA levels and race and diabetes (p < 0.05 for interaction). Conclusions: the study revealed a noteworthy inverse correlation between OBS and epilepsy among American adults. These findings underscore the potential protective effect of adherence to an antioxidant diet in reducing the prevalence of epilepsy.