[A new lignan from Cinnamomum longepaniculatum with antioxidant activity].

Source: PubMed, NCBI / U.S. National Library of Medicine

The chemical constituents of Cinnamomum longepaniculatum leaves were isolated and purified using separation techniques such as silica gel column chromatography, macroporous adsorption resin, gel column chromatography, and preparative high-performance liquid chromatography. The isolated compounds were identified by combining spectroscopic techniques including high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), nuclear magnetic resonance(NMR), ultraviolet spectroscopy(UV), and infrared spectroscopy(IR) and literature data. A total of nine compounds were identified: cinlongeligan A(1), salicifoneoliganol(2),(-)-syringaresinol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside(3), syringaresinol mono-β-D-glucoside(4), episyringaresinol-4″-O-β-D-glucopyranoside(5),(+)-medioresinol 4'-O-β-D-glucopyranoside(6), lyoniside(7), lantibetin(8),(+)-isolariciresinol-9-O-β-D-glucoside(9). Compound 1 was a novel lignan derivative. Except for compounds 7 and 9, all others were isolated from the genus Cinnamomum for the first time. The results of antioxidant activity showed that compounds 1 and 3 had significant scavenging capacity against 2,2-diphenyl-1-picrylhydrazyl(DPPH) free radical with IC_(50) values of(10.35±0.46) and(9.73±0.62) μg·mL~(-1), respectively.