A 12‐week Exercise Intervention Among Older Adults With Chronic Coronary Syndrome: Changes and Associations of Movement Behaviors and Cardiovascular Risk Factors
Source: PubMed Central Open Access, NCBI / U.S. National Library of Medicine
ABSTRACT Physical activity (PA) is key to improve the prognosis of patients with chronic coronary syndrome (CCS). This study investigated changes in movement behaviors (MB), obesity markers, cardiorespiratory fitness (VO), cardiometabolic risk (CMR), and brain‐derived neurotrophic factor (BDNF) and whether changes in MB are associated with VO, CMR, and BDNF from baseline to 9 months after a 12‐week exercise intervention. In total, 35 CCS patients (= 69.5 ± 6.4 years; 82.9% men) underwent a group‐based intervention; including two 1‐h exercise sessions per week Data was collected on anthropometrics, blood samples, cardiopulmonary exercise testing, and 7‐day accelerometry at baseline, 3‐month, and 12‐month follow‐up. Absolute changes were examined using paired‐tests. Mixed‐effects linear regression models were applied to investigate associations of MB with VO, CMR, and BDNF over time. Intra‐class correlations were calculated to estimate within‐person variability. From baseline to 3‐month follow‐up, light PA (23.7 min/d ± 10.9) increased and body mass index (−0.3 kg/m± 1.2), glucose (−0.8 mmol/L ± 0.3), and diastolic blood pressure (−2.7 mmHg ± 1.3) decreased. From baseline to 12‐month follow‐up, there were no changes in any marker. Regression models revealed no associations between any measure of habitual movement behaviors and VO, CMR, and BDNF over time. To conclude, short‐term but no long‐term changes in MB and cardiovascular health markers were observed among CCS patients af
Abstract
ABSTRACT Physical activity (PA) is key to improve the prognosis of patients with chronic coronary syndrome (CCS). This study investigated changes in movement behaviors (MB), obesity markers, cardiorespiratory fitness (VO), cardiometabolic risk (CMR), and brain‐derived neurotrophic factor (BDNF) and whether changes in MB are associated with VO, CMR, and BDNF from baseline to 9 months after a 12‐week exercise intervention. In total, 35 CCS patients (= 69.5 ± 6.4 years; 82.9% men) underwent a group‐based intervention; including two 1‐h exercise sessions per week Data was collected on anthropometrics, blood samples, cardiopulmonary exercise testing, and 7‐day accelerometry at baseline, 3‐month, and 12‐month follow‐up. Absolute changes were examined using paired‐tests. Mixed‐effects linear regression models were applied to investigate associations of MB with VO, CMR, and BDNF over time. Intra‐class correlations were calculated to estimate within‐person variability. From baseline to 3‐month follow‐up, light PA (23.7 min/d ± 10.9) increased and body mass index (−0.3 kg/m± 1.2), glucose (−0.8 mmol/L ± 0.3), and diastolic blood pressure (−2.7 mmHg ± 1.3) decreased. From baseline to 12‐month follow‐up, there were no changes in any marker. Regression models revealed no associations between any measure of habitual movement behaviors and VO, CMR, and BDNF over time. To conclude, short‐term but no long‐term changes in MB and cardiovascular health markers were observed among CCS patients after a 12‐week exercise intervention. Modeling the associations between MB and VO, CMR, and BDNF over time revealed considerable within‐person variability in the data, which should be considered in future research. Trial Registration , Retrospectively registered (20/12/2023) ejsc70208-sec-0002 Highlights Current guidelines recommend physical activity as an important component of prevention for patients with cardiovascular disease. To date, there is scarce and inconsistent evidence on changes in various cardiovascular health markers such as movement behavior including physical activity and indicators of sedentary behavior, obesity, cardiometabolic risk, cardiorespiratory fitness or biochemical processes after a 12‐week supervised exercise intervention, especially in the long term. In the present study, older adults with chronic coronary syndrome were observed at baseline, immediately afterward and 9 months after a 12‐week exercise intervention. Changes and associations between movement behavior and obesity markers, cardiorespiratory fitness, cardiometabolic risk and levels of brain neurotrophic factor concentration over time were investigated. Our results showed short‐term but no long‐term changes in cardiovascular health markers in patients with chronic coronary syndrome after the 12‐week exercise intervention. Modeling of associations over time revealed considerable within‐person variability in the data, which should be considered in future studies. bullet highlights